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Slice the squash into rounds about 1/4th of an inch thick, I like to use a mandolin for this if available and set it aside.
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In a medium-sized shallow bowl, stir together the flour, cornmeal, seasoned salt, pepper, garlic powder, and onion powder.
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In a second medium-sized shallow bowl, whisk together the buttermilk, egg, and 1 tablespoon of the flour mixture.
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Heat about ½ inch of oil in a heavy bottom skillet until it reaches 350°F.
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Take a round of squash and dip it in the buttermilk mixture, let the excess drip back into the bowl.
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Place it into the flour mixture and coat it on both sides. Shake off the excess flour.
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Carefully add it to the hot oil, and fry until lightly golden on both sides, flipping a few times to brown evenly, about 4 minutes total.
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Place it on a paper towel-lined plate to absorb any excess oil, then immediately place it on a wire rack over a sheet tray.
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Repeat steps 7 and 8 in batches with remaining sliced squash.